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Monday, July 9, 2012

FACTS ABOUT CONJOINED TWINS


HOW ARE CONJOINED TWINS FORMED?
Conjoined twins form when one sperm fertilizes one egg, but at some point during the stage where the single egg splits, the process stops, and the twins develop attached to one another. Identical twins will only be conjoined if they separate after the 12th day of conception. The twins will share a chorion, amnion and a placenta, making them monoamniotic/monochorionic and subject to TTTS (Twin to Twin Transfusion Syndrome) and cord entanglement (two reasons why many are miscarried). No one knows why conjoined twins occur, although genetic and environmental factors have been explored. 
Conjoined twins are always of the same sex. Some types (dicephalus and ischiopagus for example) may only have one set of external genitalia (or none at all), leading many misinformed news people to refer to boy/girl conjoined twins or cases where one is a boy or girl and the other is unknown (in fact, the other twin will always be the same sex as the co-twin). DNA testing has to be done to determine the sex of conjoined twins who have no external genitalia. In some cases, after separation, the twin without the external genitalia has been turned into a member of the opposite sex (seen in at least 2 cases). 

STATISTICS
Conjoined twins occur in approximately 1 in every 40,000 births, but only once in every 100,000 to 200,000 live births. 
60% of conjoined twins are either stillborn or lost in utero, and 35% of twins that survive birth die within the first 24 hours (mostly because the most common locations of conjoinment involve important systems such as the heart). Out of 100 conceptions of conjoined twins, only 26 sets will survive birth and the first 24 hours.
Conjoined twins are most likely to be female - 71.62% are girls, while 28.38% are boys. This is because male twins are more likely to be miscarried (as are all male babies).
They are most likely to occur in India or Africa than in China or the US. (Although the rates in Vietnam have been much higher in recent years, possibly due to Agent Orange exposure).
The birth rate of conjoined twins in Africa is approximately 1 in every 14,000 births. One in every 400 identical twin pregnancies will be conjoined twins.

TYPES OF CONJOINED TWINS
CEPHAALOPAGUS
Anterior union of the upper half of the body with two faces on opposite sides of a conjoined head. Joined by the face, containing a single head and two bodies. The head has a single face with four ears, two on the back of the head. This type is extremely rare and non-viable. Also called Syncephalus, Janiceps or Janus twins. 

CEPHALOTHORACOPAGUS
Fused from the head to chest. There is only one brain and head (sometimes a rudimentary 2nd face), and they usually share a heart and have fused gastrointestinal tracts. They are non-viable. They are similar to Cephalopagus, but with fusion of the chest as well as the head, and are slightly more common than true cephalopagus twins. Also called Cephalothoracopagus Syncephalus, Epholothoracopagus or Craniothoracopagus. 

THORACOPAGUS
United face-to-face from the upper thorax down to the umbilicus, with heart involvement, 90% have a shared heart and 75% have extensively conjoined hearts that can't be surgically separated. Four arms, four legs, two pelvises. Accounts for about 35% of conjoined twins.

OMPHALOPAGUS
Joined face-to-face primarily in the area of the umbilicus, and sometimes involving the lower thorax, but always preserving two distinct hearts. There is not even a cardiac vessel in common. Conjoined livers are very common. Two pelvis, four arms and four legs. Accounts for about 30% of conjoined twins. 

THORACO- OMPHALOPAGUS
Combination of thoracopagus and omphalopagus, these twins will be attached from the upper chest to the umbilicus, and will usually share a heart. About 90% of thoraco-omphalopagus twins have a common pericardium and 75% have conjoined hearts. Also may have shared livers and gastrointestinal tracts. Four arms and four legs are present. Xipho-omphalopagus twins may look more like thoraco-omphalopagus but will not have heart involvement.

XIPHOPAGUS
Joined at the xiphoid process (the smallest of the three divisions of the sternum, below the gladiolus and manubrium). They are joined roughly from the navel to the lower breastbone. These twins rarely share vital organs aside from the liver. This is a subset of omphalopagus.

ISCHIOPAGUS
United from the umbilicus to a large conjoined pelvis with two sacrum and two symphyses pubis. They are joined end-to-end with the spine in a straight line. Four arms, a variable number of legs, and in general, a single external genitalia and a single anus, but sometimes genitalia and located internally. Accounts for about 6% of all conjoined twins. 

OMPHALO- ISCHIOPAGUS
A combination of omphalopagus and ischiopagus, these twins present joined as ischiopagus twins are, but face-to-face with a joined abdomen. Four arms, and a variable number of legs are present. The main indication here is a fusion of the pelvis, which you won't see in thoraco/omphalo/xipho-pagus twins. There has also been cases of thoraco-omphalo-ischiopagus and xipho-omphalo-ischiopagus twins where the union extends upwards to the chest.

PARAPAGUS
Twins that share a conjoined pelvis, one symphysis pubis and one or two sacrums, united side by side. This type account for about 5% of all conjoined twins. It is possible for them to share a heart (if one has situs inversus of the heart), but rare. They may share the liver, kidneys and other organs. 

DITHORACIC PARAGUS
When the union is limited to the abdomen and pelvis (does not involve the thorax). This is a subset of parapagus twins. They will be of the dipus type. They will likely have their own hearts, although some will have situs inversus (reversed organs) and could possibly share a heart as well. 

DICEPHALIC PARAPAGUS(DICEPHALUS)
When the union includes the abdomen, pelvis and thorax. Dicephalus have one trunk with two heads. They are always of the dipus (two leg) type, and 3rd and 4th arms may present on their backs. This is a subset of parapagus twins. They may share a heart and other organs. The rarest type of parapagus twins is dicephalus dipus dibrachius. 

DIPROSOPIC PARAGUS
A single trunk and single head with two faces. Various degress of duplication of the face and brain can be seen. This is the most uncommon and rare type of conjoined twinning. Also called Monocephalic Diprosopos.

CRANIOPAGUS
United on any portion of the skull, except the face or foramen magnum (base of the skull). They share bones of the cranium, meninges, and occasionally brain surface. Two trunks, four arms and four legs. Accounts for about 2% of all conjoined twins. The twins can be joined end to end (vertical), at the back of the head (occipital), front of the head (frontal), side of the head (parietal/temporal). 

PYGOPAGUS
They dorsally share the sacrococcygeal, perineal regions and occasionally the spinal cord. There is one anus, two rectums, four arms and four legs. Accounts for about 19% of all conjoined twins.

RACHIPAGUS
Twins fused dorsally above the sacrum and lumbar spine, involving different segments of the column. This type is extremely rare, with only one recorded set born in 1960, joined mid-spine to the top of the head with fused skills. There have been 20 cases of rachipagus parasitic twinning.

SEPARATION 
The majority of separated twins will have some kind of disability, whether it be physical or mental. Omphalopagus and xiphopagus twins are most likely to have good health after separation. Many ischiopagus twins will have a physical disability due to the fact they often have only 2 or 3 legs between them. Craniopagus separated twins are most likely to suffer mental disabilities.


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